Heterociklična jedinjenja su ciklična jedinjenja koja pored ugljenika sadrže u strukturi prstena jedan ili više atoma nekih drugih elemenata-. Start studying Heterociklična jedinjenja (Petočlana). Learn vocabulary, terms, and more with flashcards, games, and other study tools. izvor: Wikipedia. Stranice: Poglavlja: Heterociklična Jedinjenja (2 prstena), Heterociklična Jedinjenja (3 prstena), Heterociklična Jedinjenja (4 ili više.
|Published (Last):||22 February 2006|
|PDF File Size:||19.2 Mb|
|ePub File Size:||10.20 Mb|
|Price:||Free* [*Free Regsitration Required]|
Mijin, Influence of process parameters on the photodegradation of synthesized azo pyridone dye in Ti[O. The product, of high purity, can be obtained from the reaction mixture by simple filtration. In this paper, the synthesis of the certain 2-pyridones and 2-pyridone based compounds using microwave irradiation will be discussed.
Microwave synthesis requires less acid which results in milder reaction conditions. Jovancic, Synthesis, properties and colour assessment of some new 5- 3- and 4-substituted phenylazo -4,6-dimethylcyanopyridones, J. Due to the many applications of the compounds that contain 2-pyridone structure, a number of procedures for their synthesis was developed [23,24].
Konvencionalni nacin izvodenja organskih sinteza podrazumeva zagrevanje spoljasnjim izvorima toplote pri cemu se toplota prenosi kondukcijom, sto predstavlja spor i neefikasan metod prenosa energije, jer zavisi od toplotne provodljivosti materijala, pa je temperatura reaktora veca od temperature reakcione smese. Also, malonic acid can be used. The above mentioned reactions were carried out in the presence of solvents  and in the solid state  using the conventional synthesis. Trifluoro acetic acid TFAtosic acid and pyridinium p-toluenesulfonate were used to optimize reaction conditions.
Aromatic heterocyclic compounds represent an important group of compounds due to their biological and medical applications. The obtained enaminones, without purification, react with different methylene nitriles at [degrees]C for 5 min in 2-propanol and in the presence of a catalytic amount of piperidine base.
Syntheses were performed at [degrees]C both in the conventional and the microwave method. It was demonstrated that the sulfur in the pilicide scaffold could be exchanged for oxygen with an almost retained pilicide activity.
Oh no, there’s been an error
The reaction was performed in 1,2-dichlorobenzene, in which the reactants are soluble, but the product of the reaction is not. Marinkovic, Sinteza arilazo piridonskih boja, Hem. Westman, The impact of microwave-assisted organic chemistry on drug discovery, Drug Discov.
BoxBelgrade, Serbia. Petrovic, Primena mikrotalasne tehnike u organskoj hemiji i organskoj hemijskoj tehnologiji, Hem.
Petrovic, Milrinon-svojstva i sinteza, Hem. Delgado, A novel approach to the indoloquinoline alkaloids cryptotackieine and cryptosanguinolentine by application of cyclization of ovinyl-substituted arylheterocumulenes, Tetrahedron 57 In this manner, carbostyril analogues can be synthesized Figure Dihydrooxazolo and dihydrothiazolo ring fused 2-pyridones were prepared using microwave assisted organic synthesis in good yields and high enantiomeric purity.
Synthesis of substituted 3-cyanopyridones at positions 4 and 6 was also carried out using microwave irradiation type condensation , and under conventional conditions  Figure 8.
Synthesis can be also performed in the solid phase. Tehnolosko-metalurski fakultet Univerziteta u Beogradu, Karnegijeva 4, p. Zhu, One-pot synthesis of pyridones and related compounds under microwave irradiation in water, Jiamusi Daxue Xuebao Ziran Kexueban 28 Pregled obuhvata sinteze koje su izvrsene kako u savremenim laboratorijskim mikrotalasnim reaktorima tako i one koje su izvrsene u komercijalnim mikrotalasnim pecnicama za domacinstvo.
Synthesis of 5-phenylazo-4,6-dimethylcyanopyridones and 5-phenylazo-4,6-diphenylcyanopyridone are shown in Figure 7.
HETEROCIKLIČNA JEDINJENJA by Selena Tatic on Prezi
Oikawa, Biosynthetic studies on the antibiotics PF Synthesis of 2-pyridone based bifunctional compounds 1,4-dihydropyridines by the condensation of dialdehyde, Meldrum’s acid, acetoacetic acid and ammonium acetate is another example of type condensation of pyridones Figure 11 .
The mechanism of the reaction is complex and involves Knoevenagel reaction, addition of Michael or Perkin reaction, whereby the degree of enolyzation of dioxo compounds determines the participation of Michael addition [30,31]. In this case, malondianilide was treated with Eaton’s reagent 7. Microwave synthesis was performed using a conventional microwave oven in the absence of solvent.
Kategorija:Heterociklična jedinjenja kiseonika – Wikiwand
Microwave technology is used in both synthetic steps. Agarwal, Microwave prompted multigram synthesis, structural determination, and photo-antiproliferative activity of fluorinated 4-hydroxyquinolinones, Bioorg. A randomized, placebo-controlled study, Movement Disord.
The method is applicable not only to aromatic aldehydes with electron-donor and electron-acceptor groups, but also to heterocyclic and aliphatic aldehydes.
Almqvist, Improved procedure for the enantioselective synthesis of dihydrooxazolo and dihydrothiazolo ring-fused 2-pyridones, Tetrahedron Letters 51 Hultgren, Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation, Nat.
Mijin, A Kinetic study of Candida rugosa lipase-catalyzed synthesis of 4,6-dimethylcyanopyridone, J. The thiazolines were prepared from iminoethers and cysteine while the acyl-ketenes were generated in situ from acyl Meldrum’s acid derivatives . It has antioxidant properties and is used in the treatment of hyperglycemia .
Strauss, The use of palladium on porous glass for catalytic jedinjenha reactions, Chem. It was found that the synthesis of 4-hydroxyquinolones proceeds best when an electron-donor group R is substituent in aniline. Almqvist, Microwave-assisted synthesis and functionalization of 2-pyridones, 2-quinolones and other ring-fused 2-pyridones, Top.
Besides the conventional synthesis, microwave assisted syntheses were also developed.